Modafinil
- 全部名称：
- Provigil、modafinil、莫达非尼
- 适 应 症：
- 嗜睡症
- 上市状态：
- 已批准上市
- 生产药企：
- 无
- 规格：
- 口服片剂（100毫克；200毫克）
关注度
958
什么是Modafinil？
莫达非尼是一种促进清醒的药物。
莫达非尼用于治疗由睡眠呼吸暂停、嗜睡症或轮班工作睡眠障碍引起的过度嗜睡。
莫达非尼也可能用于本药品指南未列出的目的。
与Modafinil类似的药物都有哪些？
警告提示
你不应该使用这种药物，如果你在服用莫达非尼或阿莫达非尼（Nuvigil）时曾出现过过敏反应或皮肤疹。
莫达非尼可能会引起皮肤反应，这些反应可能严重到需要住院治疗。如果你出现以下症状，请立即停止用药并寻求紧急医疗帮助：皮肤疹或荨麻疹、水疱或脱皮、口腔溃疡、呼吸或吞咽困难、发热、腿部肿胀、尿色深、皮肤或眼睛发黄、面部肿胀。
Modafinil的副作用有哪些？
如果您出现过敏反应的迹象：荨麻疹；呼吸困难；脸部、嘴唇、舌头或喉咙肿胀，请立即寻求紧急医疗帮助。
莫达非尼可引起皮肤反应，这些反应可能严重到需要住院治疗。如果您出现以下情况，请停止服用莫达非尼并立即寻求紧急医疗帮助：
皮肤疹或荨麻疹，水疱或脱皮；
口腔溃疡，吞咽困难；
发热，呼吸急促；
腿部肿胀；
尿液颜色深，黄疸（皮肤或眼睛发黄）；或
面部、眼睛、嘴唇、舌头或喉咙肿胀。
莫达非尼可能会引起严重的副作用。如果您出现以下症状，请立即停止使用莫达非尼并联系您的医生：
抑郁，焦虑，自杀念头或行为；
幻觉，异常思维或行为，攻击性，比平时更加活跃或话多；
胸痛，呼吸困难，心律不齐；或
任何皮肤疹的最初迹象，无论您认为它多么轻微。
莫达非尼的常见副作用可能包括：
头痛，头晕；
感到紧张或焦虑；
背痛；
恶心，腹泻，胃部不适；
睡眠问题（失眠）；或
鼻塞。
这并非副作用的完整列表，其他副作用也可能发生。关于副作用，请咨询您的医生以获得医疗建议。
特别注意事项
如果您在使用莫达非尼或阿莫达非尼（Nuvigil）时出现过过敏反应或皮肤疹，则不应使用莫达非尼。
为了确保莫达非尼对您是安全的，请告知您的医生以下情况：
心绞痛（胸痛）；
肝硬化或其他肝脏问题；
肾病；
高血压、心脏病或有心脏病发作的历史；
精神疾病或精神病史；或者
酒精滥用或药物成瘾史。
尚不清楚这种药物是否会对未出生的婴儿造成伤害。如果您怀孕或计划怀孕，请告知您的医生。
莫达非尼可能会降低某些避孕措施的效果。激素类避孕方法（如口服避孕药、注射剂、植入物、皮肤贴片和阴道环）可能不足以在治疗期间预防怀孕。请与您的医生讨论在服用莫达非尼期间采用的最佳避孕方法。
尚不清楚莫达非尼是否会进入母乳或是否会对哺乳婴儿造成伤害。如果您正在哺乳婴儿，请告知您的医生。
莫达非尼不适用于17岁以下的人群。
哪些其他药物会影响Modafinil？
Other drugs may interact with modafinil, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
Modafinil的用法用量
Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Modafinil may be habit-forming. Never share modafinil with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it. Selling or giving away modafinil is against the law.
Modafinil is usually taken each morning to prevent daytime sleepiness, or 1 hour before the start of a work shift to treat work-time sleep disorders.
Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.
You may take modafinil with or without food.
Modafinil is usually given for 12 weeks or less.
If you are taking modafinil to treat sleepiness caused by obstructive sleep apnea, you may also be treated with a continuous positive airway pressure (CPAP) machine. This machine is an air pump connected to a mask that gently blows pressurized air into your nose while you sleep. The pump does not breathe for you, but the gentle force of air helps keep your airway open to prevent obstruction.
Do not stop using your CPAP machine during sleep unless your doctor tells you to. The combination of treatment with CPAP and modafinil may be necessary to best treat your condition.
Modafinil will not cure obstructive sleep apnea or treat its underlying causes. Follow your doctor's instructions about all your other treatments for this disorder.
Call your doctor if you continue to have excessive sleepiness even while taking modafinil.
Taking modafinil does not take the place of getting enough sleep.
Store at room temperature away from moisture and heat.
Keep track of the amount of medicine used from each new bottle. Modafinil is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.
Usual Adult Dose for Narcolepsy:
200 mg orally once a day in the morning
Comments:
-Doses up to 400 mg orally once a day have been well-tolerated, but there is no consistent evidence of additional benefit beyond that of 200 mg orally once a day.
-In older patients, consider use of a lower dose with close monitoring.
Use: As a treatment to improve wakefulness in patients with excessive sleepiness associated with narcolepsy and OSA.
Usual Adult Dose for Obstructive Sleep Apnea/Hypopnea Syndrome:
200 mg orally once a day in the morning
Comments:
-Doses up to 400 mg orally once a day have been well-tolerated, but there is no consistent evidence of additional benefit beyond that of 200 mg orally once a day.
-In older patients, consider use of a lower dose with close monitoring.
Use: As a treatment to improve wakefulness in patients with excessive sleepiness associated with narcolepsy and OSA.
Usual Adult Dose for Shift Work Sleep Disorder:
200 mg orally once a day, approximately 1 hour prior to the start of the work shift
Use: As a treatment to improve wakefulness in patients with excessive sleepiness associated with shift work disorder.
如果我错过了一次应该怎么办？
与您的医生讨论如果错过一片莫达非尼剂量时应该怎么做。如果您不打算清醒几个小时，请避免服用此药。如果接近就寝时间，则跳过漏服的剂量。不要额外服用药物来弥补漏掉的剂量。
如果我使用过量了应该怎么办？
立即寻求紧急医疗救助。